Laurens M. De Coen, M. Jatczak, K. Muylaert
Mar 19, 2015
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0
Influential Citations
6
Citations
Journal
Synthesis
Abstract
An efficient synthesis of furo[3,4-d]pyrimidine-2,4-diones has been accomplished via a straightforward three-step pathway. Curtius rearrangement of 4-(methoxycarbonyl)furan-3-carboxylic acid and subsequent reaction with a variety of amines resulted in the corresponding intermediate ureids, which could be ring closed to the bicyclic scaffold in good yields. Functionalization of N-1 afforded a small library of new heterocycles. (Partial) hydrogenation of the furo[3,4-d]pyrimidine-2,4-diones led to the 5,7-dihydro- and tetrahydrofuro[3,4-d]pyrimidine-2,4-diones.