P. Lindberg, A. Brandstrom, B. Wallmark
Oct 1, 1987
Citations
0
Influential Citations
43
Citations
Journal
Trends in Pharmacological Sciences
Abstract
Abstract Omeprazole represents a new class of gastric acid secretion inhibitors, the sulphinylbemimidazoles . Per Lindberg and colleagues describe this first example of a clinically useful anti-ulcer agent in this group whose mechanism involves highly specific inhibition of H + /K + -ATPase, the gastric proton pump. Omeprazole is activated only at low pH, as occurs in the parietal cell and is thus highly selective. The active intermediate formed, a sulphenamide, reacts with a mercapto group of H + /K + -ATPase to form a disulphide inhibitor complex. The quantity of this sulphenamide on the luminal side of the parietal cell is related to the H + /K + -ATPase inhibitory effect .