L. Quijano, J. Calderón, Gisel Gómez
Aug 21, 1984
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0
Influential Citations
17
Citations
Journal
Phytochemistry
Abstract
Abstract A chloroform extract of Montanoa grandiflora afforded a novel 6β-hydroxy-germacradien-8,12-olide. Its structure was shown to be 6- epi -desacetyllaurenobiolide by spectral studies, chemical transformations and single crystal X-ray diffraction. The X-ray data demonstrate that the ten-membered ring exists in the crystal in the highly unusual [ 15 D 5 , 1 D 14 ] conformation, in which the methyl group at C-4 is α-oriented and the methyl group at C-10 is β-oriented. The two double bonds are approximately parallel rather than crossed.