Xu-Yang Zhang, Bing-Ni Liu, Ping-Bao Wang
Sep 24, 2014
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Acta Crystallographica Section E: Structure Reports Online
Abstract
The title compound, C18H17BrO2, is a key intermediate in the synthesis of lomitapide mesylate, a microsomal triglyceride transfer protein inhibitor. Its asymmetric unit contains two independent molecules with slightly different conformations; the mean planes of the 4-bromobutyl and carboxylate groups in the two molecules form dihedral angles of 24.54 (12) and 17.10 (18)°. In the crystal, carboxylate groups are involved in O—H⋯O hydrogen bonding, which leads to the formation of two crystallographically independent centrosymmetric dimers. Weak intermolecular C—H⋯O interactions further link these dimers into layers parallel to the bc plane.