Yuxiang Dong, K. J. Mccullough, S. Wittlin
Nov 15, 2010
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
An unsaturated dispiro 1,2,4,5-tetraoxane formed by peroxidation of (+)-dihydrocarvone was converted into four structurally diverse derivatives. X-ray crystallographic analysis shows that the structures possess central tetraoxane rings with spiro-2,5-disubstituted cyclohexylidene substituents and 6-membered rings in classical chair conformations. As polarity in the tetraoxane series increased, in vitro potency against Plasmodium falciparum decreased.