S. Rakhit, K. Singh
Mar 1, 1974
Citations
0
Influential Citations
19
Citations
Journal
The Journal of antibiotics
Abstract
Leucomycin (Kitasamycin) is a macrolide antibiotic having activity against gram-positive bacteria and certain Mycoplasma strains. Comparison of antimicrobial activities of the variuos leucomycin congeners (I-X) indicates a clear structure-activity relationship among them. The acylation of the 3-hydroxy group somewhat reduces the in vitro activity while the acylation of the 4"-hydroxy group of mycarose produces higher activity. The activity is dependent on the length of the acyl