M. Yokota, H. Uekusa, Y. Ohashi
Aug 1, 1999
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0
Influential Citations
11
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Two crystal forms of (−)-trans-4-(p-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine hydrochloride salt (paroxetine HCl) have been analyzed by X-rays. One form (Form I) is obtained as a hemihydrate and the other (Form II) is crystallized as the propan-2-ol solvate. The crystal of Form I belongs to the monoclinic system and the space group is P21. The unit-cell dimensions are; a = 14.5888(10), b = 10.1591(7), c = 13.0255(10) A, β = 107.095(3)°, and V = 1845.2(2) A3. There are two crystallographically independent protonated paroxetine molecules with different conformations and chloride anions, and one water molecule in an asymmetric unit. The crystal of Form II also belongs to the monoclinic system and the space group is P21. The unit-cell dimensions are; a = 11.6504(7), b = 5.7374(3), c = 16.4107(10) A, β = 90.959(2)°, and V = 1096.79(11) A3. There are one protonated paroxetine molecule, one chloride anion, and one solvent propan-2-ol molecule in an asymmetric unit. The protonated paroxetine mol...