Koo Chung Hoe, K. Hern, Shin Wanchul
1985
Citations
0
Influential Citations
13
Citations
Journal
Bulletin of The Korean Chemical Society
Abstract
The crystal structure of sulindac, , one of the nonsteroid antiinflammatory agents, has been determined by the X-ray diffraction techniques using diffractometer data obtained by the scan technique with Cu $$ radiation from a crystal with space group symmetry Pbca and unit cell parameters a = 8.166(1), b = 18.291(8), c = 23.245(10) The structure was solved by direct methods and refined by full-matrix least-squares to a final R = 0.11 for the 1153 observed reflections. The carboxyl group is nearly perpendicular to the indenyl ring as observed in indomethacin. The dihedral angle between the indenyl and phenyl rings is the corresponding angle in indomethacin is Crystal packing consists of a hydrogen bond and partial ring stacking between the indenyl rings.