Xue Si-jia
2012
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0
Influential Citations
1
Citations
Journal
Journal of Shanghai Normal University
Abstract
A novel compound N-(4-methylbenzyl)-3,5-bis(4-chlorobenzylidene)-4-pip-eridone was synthesized with 4-methylbenzylamine as raw materials via a series of Michael addi-tion,Dieckmann condensation,hydrolysis decarboxylation and Aldol condensation.The structure was confirmed by elemental analysis,1H NMR,IR,ESI and single-crystal X-ray diffraction.The crystal belongs to the monoclinic system,with space group P2(1) corresponding to a=17.1226(16),b=6.28396(6),c=21.468(2),α=90°,β=99.753°,γ=90°,V=2276.5(4) 3,Z=4,Dc =1.308 g/cm3=0.304 mm-1,Mr=448.36,F(000)=936,S=1.019,the final R=0.0585 and wR =0.1456.The molecule was nonplanar,and the piperidine ring exhibited a sofa conformation.The carbon-carbon double bonds in the compound were both E-configuration.Neither intranor intermolecular hydrogen bonds was identified in the crystal structure.Assay-based antiproliferative activity study using leukemic cell lines K562 revealed that the compound had high effectiveness in inhibiting leukemia K562 cells proliferation.