A. Cameron, G. Ferguson
1969
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Journal
Journal of The Chemical Society B: Physical Organic
Abstract
An unexpected product of formula C18H20O3, obtained by treatment of β-dimethylaminopropiophenone at its boiling point with isophorone, has been shown to be 2-benzoyl-1,5,5-trimethylbicyclo[2,2,2]octa-6,8-dione by a single-crystal X-ray analysis of the p-bromo-derivative. The crystals, of formula C18H19O3Br, are monoclinic, space group P21/c with Z= 4 in a unit cell of dimensions a= 17·71, b= 9·25, c= 10·63 A, and β= 106·5°. The structure was solved by the heavy-atom method and refined by least-squares calculations to R 0·099 for 1828 reflexions. The elucidation of the structure has yielded further information about the mechanisms of thermal Michael condensations.