Y. Azev, Detlef Gabel, E. Lork
Jul 1, 2006
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Journal
Pharmaceutical Chemistry Journal
Abstract
The structures of crystalline fervenulin, 2-methylfervenulin-3-one (MSD-92), and their 4-N-oxides were studied using x-ray diffraction and 1H and 13C NMR spectroscopy techniques. Acomparative analysis of the spectroscopic data and the chemical reactivity of pyrimidotriazine antibiotics and their analogs allowed the reactive centers of these biologically active compounds, ways of their activation, and mechanisms of transformation to be elucidated.