B. Khan, K. Venkatasubramanian, K. Najmuddin
Jan 2, 1991
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0
Influential Citations
22
Citations
Journal
Inorganica Chimica Acta
Abstract
Abstract The crystal and molecular structure of patent compound cis -dichloroethionineplatinum(II) was determined by X-ray diffraction method. The complex crystallises with 4 molecules in the monoclinic space group P 2 1 /n with a cell of dimensions a = 7.223(1), b = 14.435(1), c = 11.012(2) A, β=97.69(2)°. The structure was solved by the heavy atom method and has been refined to an R value of 0.031 for 1573 observed reflections. In cis -dichloroethionineplatinum(II), the ethionine molecule coordinates to the platinum through the amino nitrogen and sulfur atoms to form a six-membered ring which adopts a skewed chair conformation. The predominant force of packing in this complex is the intermolecular hydrogen bonding between the two free carboxylic acid groups of adjacent molecules of ethionine. These are reinforced by weak NH…Cl bonds to stabilise crystal packing. Mixed ligand complexes of Pt(II)ethionine with adenine, adenosine, hypoxanthine, ionosine, cytosine and cytidine were synthesised and characterised by elemental analysis, conductivity measurements, IR and 1 H NMR spectral studies. In the complexes of adenine, adenosine, hypoxanthine and ionosine the ligand binding site to the metal ion is N 7 , whereas in the case of cytosine and cytidine the binding site is N 3 .