Biswas Goutam, I. Iitaka, D. Shugar
1989
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0
Influential Citations
3
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Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract Isocytosines are formal analogue of isoguanines for pairing with hydrogen bonds and are substrates for target enzymes for chemotherapy of infections diseases. The compound 5-bromo-6-benzylamino isocytosine crysta-Nized in space group P21/c with a =11.393(1)A. b = 7.341(2)A, c = 14.425(1) A, β = 92.06(2)°. The structure was determined by heavy atom methods and refined by full matrix least squares to R = 6.8% based on 1935 X-ray structure amplitudes. The isocytosine ring in the molecule is protonated at N(3) with internal bond angle of 122° compared to 117° at N(1). The structure is stabilized by intermolecular hydrogen bonding pattern based on N-H.N and N-H…O hydrogen bonds.