J. Guillon, M. Marchivie, Yvonnick Loidreau
Dec 23, 2013
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Abstract
The complete crystal structure of N-(3,4-dimethoxyphenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine, synthesized via a Dimroth rearrangement and designed as new inhibitor of CLK1 and DYRK1A kinases, was established by a single-crystal X-ray diffraction. The crystal is orthorhombic, space group Pca21; , , A, °, A3, and , C17H14N4O2S. Solid-state data could be used to enlighten the biological mechanism of action.