Luo Xian
2011
Citations
0
Influential Citations
2
Citations
Journal
Chemical Journal of Chinese Universities-chinese
Abstract
In order to find novel insecticides with high activity,a series of 4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)-N-(aryl)thiazol-2-amines was synthesized from 2-(2-methylallyloxy)phenol with Claisen rearrangement,cyclization of furan,etherification,Friedel-Crafts acylation,α-bromation and cyclization of thiazole.Their structures were confirmed by mass spectrometry(MS),1H NMR spectra and elemental analysis.The crystal structure of compound 7j was determined by X-ray diffraction analysis.The crystal belongs to the monoclinic system,space group C2/c with a=2.21140(12) nm,b=0.87602(5) nm,c=2.13911(12) nm,β=115.5380(10)°;V=3.7391(4) nm3,Z=8,Dc=1.375 g/cm3,F(000)=1616,S=1.046,μ=0.333 mm-1,the final R1=0.0390 and wR2=0.1079.The preliminary bioassays indicated that compound 7a,7b,7h and 7t exhibited insecticidal activity against Aphis fabae were 95.12%,62.60%,57.53% and 59.06%,respectively,at 500 mg/L.