Aveary R Menze, Jefferson P Sinnott, A. Nazarenko
Jun 13, 2017
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Journal
Acta Crystallographica Section E: Crystallographic Communications
Abstract
Naltrexone [systematic name: 17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one] is an opioid receptor competitive antagonist that has been widely used to prevent relapse in opioid- and alcohol-dependent subjects. Its chloride salt forms non-isomorphic solvates with ethanol (C20H24O4 +·Cl−·C2H5OH) (I), propan-2-ol (C20H24O4 +·Cl−·C3H7OH) (II), and 2-methylpropan-2-ol (C20H24O4 +·Cl−·C4H9OH) (III). In all these structures, the alcohol molecules occupy infinite solvent-filled channels. All three compounds described are attractive crystalline forms for unambiguous identification of naltrexone chloride after isolation from a pharmaceutical form.