A. Starratt, B. E. Brown
Oct 15, 1975
Citations
4
Influential Citations
282
Citations
Quality indicators
Journal
Life sciences
Abstract
Abstract Proctolin, a myotropic substance with potent activity on the proctodeal (hindgut) muscles of the cockroach, Periplaneta americana (L.), has been identified by the use of Edman degradation and dansylation techniques as Arg-Tyr-Leu-Pro-Thr. Synthesis of the pentapeptide having this sequence and exhibiting the properties of natural proctolin confirmed the structure. Threshold activity on proctodeal muscle occurs at about 10−9 M proctolin.