M. Caira, F. de Wet, J. Gerber
Feb 1, 1999
Citations
1
Influential Citations
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Citations
Journal
Journal of Chemical Crystallography
Abstract
The preparation, single crystal x-ray structure and the computed powder XRD pattern of a monoclinic polymorph of N-[4-(acetyloxy)phenyl]acetamide, a prodrug of acetaminophen, are reported. The polymorph crystallizes in the space group P21/n with Z = 4 and unit cell dimensions a = 7.219(2), b = 8.015(2), c = 16.575(2) Å, β = 92.07(1)°, and V = 958.4(4) Å3. Infinite spiral molecular arrays result from intermolecular head-to-tail hydrogen bonding between the amidic H atom of one molecule and the acetoxy carbonyl oxygen atom of a 21-related molecule.