G. Coquerel, M. Petit, F. Robert
Apr 15, 1993
Citations
0
Influential Citations
8
Citations
Journal
Acta Crystallographica Section C-crystal Structure Communications
Abstract
The structure of (+)-(S)-5-phenyl-5-ethyl-2,4-imidazolidinedione or (+)-(S)-5-phenyl-5-ethylhydantoin (PHETHYD) is determined and compared with the structure of other related anticonvulsants. Among all the hydantoin derivatives previously described, the conformation of PHETHYD exhibits the smallest value (60°) of the dihedral angle between the phenyl ring and the hydantoin ring. The hydrogen-bond network suggests a particular stability of the homochiral packing. The two N-H and C=O bonds participate in the hydrogen-bond network which forms a flat ribbon parallel to the a axis. The non-polar parts of the molecules are facing each other and are held together by van der Waals forces only