K. Bowden, K. Wooldridge
1973
Citations
0
Influential Citations
11
Citations
Journal
Biochemical pharmacology
Abstract
Abstract A correlation of the bronchodilator activity of a series of substituted 6-thioxanthines has been made with partition parameters and/or the steric “bulk” of the 1- and 3-substituents. The 3-substituted series are correlated by a Hansch relation involving partition factors alone. Steric factors appear to be important for substitution at the 1-position. In general, an increase in activity is observed on introduction of “bulky” substituents at both these positions. The significance of these results is discussed.