P. Franchetti, M. Grifantini, S. Martelli
Jul 1, 1969
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
The methiodides derived from 2-hydroxyimino-1-pyridyl-ethan-1-ones, 2-hydroxyimino-1-pyridyl-1-hydroxyethanes, and 1,2-di(hydroxyimino)-1-pyridylethanes were tested as reactivators of phosphorylated acetylcholinesterase. The most active member, 2-hydroxyimino-1-(2′-pyridyl)-ethan-1-one, displays a rate of reactivation, in the case of tetraethyl pyrophosphate poisoning, slightly higher than that of the well-known reactivator 2-hydroxy-iminomethyl-1-methyl-pyridinium iodide.