A. Janecka, J. Fichna, M. Mirowski
Nov 30, 2002
Citations
0
Influential Citations
14
Citations
Journal
Mini reviews in medicinal chemistry
Abstract
Morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) is one of the most selective agonists for the mu-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.