S. Ebdrup, P. Jacobsen, Anupma Dhanda Farrington
Mar 15, 2005
Citations
1
Influential Citations
28
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl)boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2-boronic acid were found to be the most potent HSL inhibitors with IC(50) values of 140, 17 and 350 nM, respectively.