E. Teodori, S. Dei, A. Garnier‐Suillerot
2001
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Medicinal Chemistry Research
Abstract
A few derivatives of the potent MDR inhibitor 2-(3,4-dimethoxyphenyl)-2-(methylethyl)-5-[(anthr-9-yl)methylamino]pentanenitrile (MM36) have been synthesised and studied with the aim of optimising activity and selectivity.The results show that, even if dramatic improvements in potency and in selectivity were not reached, a better drug candidate (14) and a new lead for further development of the series (8) have been identified.