R. Baldwin, T. Lin, H. S. Winchell
Mar 1, 1981
Citations
0
Influential Citations
2
Citations
Journal
Journal of Radioanalytical Chemistry
Abstract
Abstracto-Iodobenzamide is a stable compound which is labeled quantitatively by heating with no-carrier-added123I-NaI in ethanol. The123I product is relatively inert biologically, being resistant toin vivo deiodination or hydrolysis, in rats and dogs, for several hours. Furthermore, it appears to be freely diffusible, distributing itself in the body according to the extravascular fluid space, with some localization in the liver, and little tendency for excretion into the urine or bile. The brain uptake and brain-blood ratio is higher than that of iodoantipyrine, and allows imaging the brain in dogs. The product is also taken up by induced myocardial infarcts and transplanted tumors in rats. Substitution of the amide function with single alkyl groups does not greatly alter thein vivo characteristics except at long-chain length where hepatobiliary excretion predominates. Substitution of both amide hydrogens, however, results in a different pattern, with high blood binding and increased excretion. Conversion to more polar functionalities, such as the hydrazide or hydroxamic acid, also leads to hepatobiliary excretion.