A. Shahripour, M. Plummer, E. Lunney
Oct 22, 2001
Citations
0
Influential Citations
18
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of compounds was designed and prepared as inhibitors of interleukin-1beta converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable interactions between the diphenyl ether rings and the prime side hydrophobic region. An X-ray crystal structure of a representative member of the diphenyl ether sulfonamide series bound to the active site of caspase-1 was obtained.