Tadashi Terasaka, Isao Nakanishi, Katsuya Nakamura
2003
Citations
0
Influential Citations
17
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We searched for non-nucleoside inhibitors of adenosine deaminase by rational structure-based de novo design and succeeded in the discovery of 1-(1-hydroxy-4-phenyl-2-butyl)imidazole-4-carboxamide (FR221647: K(i)=5.9 microM to human ADA) as a novel inhibitor with moderate activity and good pharmacokinetics compared with the known inhibitors pentostatin and EHNA.