C. Wei, C. McLaughlin
Apr 8, 1974
Citations
1
Influential Citations
79
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract An important group of mycotoxins, the 12,13-epoxytrichothecenes (Fig. 1), are among the most active inhibitors of protein synthesis in eucaryotic cells. Some of these compounds inhibit a step required for the initiation of protein synthesis, while other compounds inhibit a step required for the termination or elongation of protein synthesis. Structure-function studies on the various derivatives indicate which areas of the molecule are important in the inhibition of initiation and termination or elongation.