P. Pecorari, M. Rinaldi, Maria Paola Costi
Mar 12, 2009
Citations
0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Derivatives of two new molecular structures, namely, [1,3] thiazino [3,2-a] purine and [1,2,3] triazolo [4,5-d]-[1,3] thiazino [3,2-a] pyrimidine, were synthesized together with other heterocyclic compounds. Retrosynthetic analysis of their molecular skeletons suggested a simple way of obtaining 3,4-dihydro-7,8-diamino-2H,6H-pyrimido [2,1-b][1,3] thiazin-6-one, which is a useful intermediate for their synthesis. This intermediate and the thiazole homologue were obtained directly by reaction of 5,6-diamino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone with 1,3- or 1,2-dibromoalkane, respectively