Y. Jiao, C. Cao, Xiao-lin Zhao
Nov 14, 2012
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Influential Citations
8
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract The 1,3-diol moiety is present in a number of natural products and has some biological activity. Four symmetric anti -2,4-bis(X-phenyl)pentane-2,4-diols ( a , X = p -F; b , X = p -CF 3 ; c , X = m -OMe; d , X = m -CF 3 ) have been characterized by X-ray diffraction, and the results indicated that the dihedral angles between the every two benzene rings in the systems are 34.38(10)°, 39.46(13)°, 23.42(7)°(A), 30.42(7)°(B) and 44.74(9)°, respectively. All of the structures were stabilized by classical intra- and intermolecular hydrogen bonding and some other weak interactions. It was observed that the hydrogen bonding patterns were formed between each single-molecule in compounds a – d , whereas H-bonding dimers were formed in the crystal lattices of both the anti - and syn-2,4-bisphenylpentane-2,4-diols. The four symmetric diaryl 1,3-diols were evaluated alongside several other 1,3-diols as potential antifungal agents, and their in vitro antifungal activities were measured against several fungal species, including Gibberella zeae , Botrytis cinerea , Alternaria alternata and Sclerotonia sclerotiorum .