M. Abdel-Monem, T. O. Soine
Aug 1, 1967
Citations
0
Influential Citations
3
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The structures of three products encountered during structural studies on argemonine and (±)-N-methylpavine (I) have been determined. The first of these, obtained by hydrochloric acid treatment of 3-hydroxy-2′:3′:2″:3″-tetramethoxy-1:2–5:6-dibenzoocta-1:5:7-triene (II), has been determined to be 3-chloromethyl-2′:3′:2″:3″:-tetramethoxy-1:2–4:5-dibenzocyclohepta-1:4:6-triene. The second, known as argemoninic acid and resulting from permanganate oxidation of II, has been shown to be 2:2′-dicarboxy-4:5:4′:5′-tetramethoxybenzil. The third product, resulting from alkaline ethyl chloroformate treatment of I, has been shown to be the corresponding N-carbethoxy derivative of pavine.