Yang Zai
2015
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Journal
Chinese Journal of Inorganic Chemistry
Abstract
The Phenyl-acetic acid furan-2-ylmethylene-hydrazide(H2L: C13H12N2O2) was synthesized from methyl phenylacetate, hydrazine hydrate and furfural, and then reacted with nickel chloride hexahydrate to form a complex Ni(HL)2(1). The structures of H2 L and 1 were determined by X-ray single crystal diffraction and element analysis.The X-ray single crystal diffraction showed that the crystal of H2 L belonged to monoclinic system, space group P21/c with a=1.161 9(3) nm, b=1.359 8(3) nm, c=0.792 16(19) nm, β=109.307(4)° and the crystal of the complex 1 belonged to triclinic system, space group P1 with a=0.455 70(14) nm, b=1.094 7(3) nm, c=1.204 8(4)nm, β=98.302(5)°. Thermal gravity analyses were used to investigate the thermal stabilities of H2 L and 1, and the apparent activation energy(Ea) of the decompositions were also calculated, and the results indicated that the complex 1 was more thermal stable than the ligand H2 L. The microcalorimetric method was used to study the interactions of H2 L and the complex 1 with calf thymus DNA(CT-DNA), and the experimental results showed that the enthalpy change(ΔH) of the complex 1 was greater than that of the ligand H2 L, indicating that the complex 1displayed stronger interaction with CT-DNA than the ligand H2 L. CCDC: 909434, H2L; 949203, 1.