J. Casida, M. Eto, A. Moscioni
May 1, 1976
Citations
2
Influential Citations
81
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract Many 2,6,7-trioxabicyclo[2.2.2]octanes with P, PO, PS, CH or C-alkyl substituents in the 1-position and C2H5, n-C3H7, i-C3H7, n-C4H9, or other substituents at the 4-position act at very low intraperitoneal dosages to produce convulsive seizures and death in mice. The signs of poisoning, probably resulting from stimulation of the central nervous system, resemble those of 2,6-dithia-1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane-2,2,6,6-tetroxide and 1-(p-chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane, which are of similar toxicity to 4-isopropyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane and its 1-oxide and 1-sulfide derivatives. It appears likely that toxicants of several of the chemical classes represented within the 67 compounds that were studied act at the same site in the central nervous system without having a requirement for metabolic activation. Synthesis procedures are reported here for many of these toxic materials. The findings of this study are relevant to the hazards associated with certain intermediates used in coordination chemistry and organic synthesis and with the combustion products of some flame retardants in the presence of certain polyols.