S. East, M. Joullié
Oct 1, 1998
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0
Influential Citations
17
Citations
Journal
Tetrahedron Letters
Abstract
A strained 14-membered cyclopeptide was prepared from the Garner aldehyde derived from D-serine. The key steps in the synthesis were the construction of the alkyl-aryl ether linkage via an SNAr reaction involving 4-fluorobenzonitrile and the macrolactamization using a modification of the Schmidt protocol involving an activated pentafluorophenyl ester.