Mari Sithambaram Karthikeyan, Dasappa Jagadeesh Prasad, Manjathuru Mahalinga
2008
Citations
0
Influential Citations
46
Citations
Journal
European journal of medicinal chemistry
Abstract
A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities.