Ofentse Mazimba, Khumo Mosarwa
Apr 1, 2015
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Journal
International Journal of Chemical Studies
Abstract
This review describes the recent literature surveyed regarding the synthesis of 2,4-diaryl-3azabicyclo[3.3.1]nonanone (3-ABNs) and their biological activities in the last six years (2008-2014). These heterocyclic compounds are obtained from the Mannich reaction of ketones, aldehydes and ammonium acetate in polar aprotic solvents. The carbonyl group enables the functionalization of 3-ABNs into sulphur and nitrogen containing heterocycles such as hydrazones, oximes, hydrazide, thiazoles, amides and semicarbazones. The 3-ABNs heterocycles exist in chair-chair and/or boat-chair conformations with equatorial phenyl groups. From the surveyed literature studies the major importance was given to their biological activities against the different fungal and bacterial strains. The structure activity relationship indicated that electron withdrawing groups at the ortho and para position of the aryl rings enhanced the antibacterial and antifungal activities.