S. Naito, Y. Ueno, H. Yamaguchi
Feb 1, 1971
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Blood levels of 4-(aminoethanesulfonylamino)antipyrine in rabbits were determined, and binding of the chemical with rabbit serum in vivo and in vitro was examined. Metabolites of the chemical in rabbit urine were separated into five compounds: rubazonic acid (trace), 4-aminoantipyrine, 4-acetylaminoantipyrine, 4-hydroxyantipyrine (trace), and unchanged chemical. Glucuronide in urine of rabbits administered with 4-(aminoethanesulfonylamino)antipyrine is the conjugated form with 4-hydroxyantipyrine. Some pharmacological activities were investigated; it was observed that the chemical shows analgesic, anti-inflammatory, antihistaminic, and antipyretic actions.