K. Kameo, K. Ogawa, K. Takeshita
Jun 25, 1988
Citations
0
Influential Citations
29
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
As part of the search for new antirheumatic agents, three types of 3-benzoylpropionic acid derivatives having a mercapto moiety in their structures were prepared, and tested for suppressing activity on adjuvant arthritis in Sprague-Dawley rats. A structure-activity relationship study showed that substitution on the phenyl ring contributed to the activity and the most favorable substituent was different in each type of derivative.