M. Kinoshta, S. Nakada, S. Umezawa
Apr 1, 1967
Citations
0
Influential Citations
2
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
In continuing our study of the relationship between structural and antitumor activity, α-acetylamino acids containing a terminal methyleneketo group (namely, 2-acetamido-5-oxo-6-heptenoic acid, and 2-acetamido-4-oxo-5-hexenoic acid) and related derivatives have been synthesized. Their structures were confirmed by a study of their chemical reactions and their ultraviolet and infrared absorption spectra. It has been found that methyl esters of the α-acetylamino acids showed significant antitumor activity, whereas the free N-acetyl acid failed to show such activity.