Ananthanarayanan Cv, N. Anand, Bindra Js
Feb 1, 1977
Citations
0
Influential Citations
3
Citations
Journal
Indian journal of chemistry
Abstract
Synthesis of hexa- and octa-hydrophenanthrene derivatives, specifically that of 1,2-trans-7-hydroxy-1-phenyl-1,2,3,4,9,10-hexahydrophenanthrene-2-carboxylic acid, are reported. 2 alternative methods of creating this compound are described in step-by-step detail, and diagrams depicting the chemical structures are provided. These hydrophenanthrene derivatives were synthesized to discover if, as do the related compounds cis-bisdehydrodoisynolic acid and cyclohexanecarboxylic acid, they exhibited marked estrogenic and postcoital antifertility control activities. Derivatives reported here were tested for their anti-implantation activity in mated albino rats; none of them prevents implantation at a 10-millig/kilog dose.