S. Hayashi, M. Furukawa, Y. Fujino
Oct 25, 1971
Citations
0
Influential Citations
3
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
Several bis (2, 3-epoxypropyl) amine derivatives were successfully synthesized by the modification of Homer's method. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene were attempted to react with thiols, amines and phenol, and the corresponding ring opening compounds of the epoxide ring were obtained in good yields, respectively. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene also reacted with diethyl malonate to give N, N'-bis (γ-ethoxycarbonyl-γ-butyrolacton-α-yl) methyl piperazine and p-bis (γ-ethoxycarbonyl-γ-butyrolacton-α-yl) methoxy benzene, respectively.