B. Razdan, Ashok Sharma, K. Kumari
Nov 1, 1987
Citations
1
Influential Citations
7
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract The spasmolytic activity of the lactams, 9-methyl-3,9-diazabicyclo[4.2.1]nonan-4-one 1 and 10-methyl-3,10-diazabicyclo[4.3.1]decan-4-one 2 and their reduction products, 9-methyl-3,9-diazabicyclo[4.2.1]nonane 3 and 10-methyl-3,10-diazabicyclo[4.3.1]decane 4 are described. Syntheses and spasmolytic effects of new amides and sulfonamides of the amines 3 and 4 are also reported. 3 possessed specific anti-serotonin activity. Amides of 3 with aromatic acids resulted in specific anti-histaminic compounds, whereas amides of 4 with aliphatic acids showed spasmogenic activity. A number of amides and sulfonamides showed non-specific spasmolytic activity.