N. N. Kansagara, J. N. Godhasra, M. Patel
Jan 12, 2010
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ChemInform
Abstract
The series of 4-aryl-6-isopropyl-5-[N-(3-nitrophenyl)aminocarbonyl]-3,4-dihydropyrimidin-2(1H-thiones 2a-1 were prepared via arylidene (route-1) intermediates by condensing 2-arylidene-4-methyl-N-(3-nitrophenyl)-3-oxopentanamide and thiourea in the presence of potassium bicarbonate. Then 2a-1 were prepared by single step (route-2) in the presence of conc. HCl catalyst, with better yield in short time compare to route-1. Some of these compounds showed potential antimicrobial activity.