T. Sugimoto, K. Shibata, S. Matsuura
Oct 1, 1979
Citations
0
Influential Citations
6
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Synthesis of some pyrimidines and pteridines with an amino acid residue at the 2-position was investigated. 4-Ammo-6-hydroxy-2-methylthio-5-nitrosopyrimidine, on heating with amino acids in water, underwent aminolysis at the 2-position to give the corresponding N-(4-amino-6-hydroxy-5-nitroso-2-pyrimidinyl) amino acids. These (5-nitroso-2-pyrimidinyl)amino acids, after reduction of the nitroso group to an amino group, condensed with biacetyl or a pentose phenylhydrazone to give N-(4-hydroxy-6,7-dimethyl-2-pteridinyl) amino acids and N-(4-hydroxy-6-polyhydroxypropyl-2-pteridinyl) amino acids, respectively.