Antonio J. Bustillo, C. M. García-Pajón, J. Aleu
Nov 28, 2003
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The metabolism of (±)-1-(4′-chlorophenyl)-2-phenylethanol 1 by the phytopathogenic fungi Colletotrichum gloeosporioides and Botrytis cinerea has been studied. Regioselective monooxygenase-catalyzed hydroxylation of CH bonds yielded the corresponding diols, the ratios of which showed a clear preference for the CH benzylic bond. m -Hydroxylation in the substituted aromatic ring, a rarely described phenomenon, has been observed and with good enantioselectivity. The chemistry involved in determining the configuration of the biotransformation products is also described.