S. Majumdar, M. Solomon
Jun 1, 1971
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Journal
Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie
Abstract
Cytogenetic studies in Mongolian gerbils, Meriones unguiculatus, have shown that calcium cyclamate when given intraperitoneally can induce hyperploidy and chromosomal breaks, gaps, and fragments in bone marrow cells in vivo. Increasing concentrations of the sweetener produced increasing incidence of chromosomal abnormalities. Analysis of means showed that a 'saturation effect' of calcium cyclamate to induce hyperploidy, breaks and fragments was reached at 150 mg/kg; whereas a dose-response relationship was found between increasing concentrations (except at 50 mg/kg) and increasing percentage of cells showing gaps. The ability of calcium cyclamate to produce hyperploid cells and fragments is revealed for the first time in this study.