I. Rosenblum, A. Wohl, A. Stein
1965
Citations
0
Influential Citations
34
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The purpose of this study was to determine the mechanisms by which lesion-producing doses of some representative sympathomimetic amines could cause impairment of myocardial function. Impairment of myocardial function was indicated when the aortic outflow was significantly lowered by lesion-producing doses of all the test drugs. The probable mechanisms of impairment differed among the drugs, thus confirming the pluricausal origin of drug-induced myocardial necrosis. Three mechanisms for impairment of function are proposed. Ephedrine, methoxamine, and norephedrine acted through a myogenic mechanism manifested as a reduction in myocardial contractile force. Nordefrin and norepinephrine acted through a physical mechanism by causing an increase in mean aortic pressure which opposed left ventricular pressure. Isoproterenol probably acted by a third mechanism which is believed to be at the level of myocardial utilization of substrate.