E. Hoggarth, A. R. Martin
Sep 1, 1951
Citations
0
Influential Citations
3
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
A degree of antituberculous "activity" in experimental animals has been detected with certain benzaldehyde thiosemicarbazones (I) by a number of workers (Domagk, Behnisch, Mietzsch, and Schmidt, 1946; Hoggarth, Martin, Storey, and Young, 1949). One compound of this type (p-acetylaminobenzaldehyde thiosemicarbazone) has had extensive clinical trials in Germany, and these trials have been critically reviewed by Hinshaw and McDermott (1950). In man, therapeutic effect is accompanied by a considerable risk of toxic side-effects, and we have made attempts to improve upon the activity and reduce the toxicity of these drugs by chemical modification of them.