D. Hamre, K. Brownlee, R. Donovick
Oct 1, 1951
Citations
1
Influential Citations
55
Citations
Quality indicators
Journal
Journal of immunology
Abstract
Summary A series of thiosemicarbazones were studied for antivaccinial activity in chick embryos and in mice. Of those studied, benzaldehyde, 3-thiosemicarbazone, its p-acetamido, p -amino, p -methoxy, p -propoxy and p -ethylsulfonyl analogs were the most effective against vaccinia in chick embryos. In mice infected intranasally with vaccinia, benzaldehyde, 3-thiosemicarbazone, its p -acetamido analog and the N 4 isobutyl derivatives of these two compounds were the most effective, but only at doses near the maximal tolerated dose administered in the diet two days prior to infection and for ten days after infection.