R. Akuamoah, P. E. Brown, W. Y. Marcus
1995
Citations
0
Influential Citations
9
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
3-Bromination of 7-methoxy-2,2-dimethylchroman-4-one 3a stabilises the anion 2a obtained on deprotonation with LDA sufficiently for 3-alkylation to take place without the usual ring-opening. Methylation in the presence of copper(I) bromide results in 3,3-dimethylation in good yield.